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Methadone is an opioid used for opioid maintenance therapy, to help with tapering in people with opioid dependence, and for pain. Detoxification by using methadone either relatively rapidly in less than a month or gradually over as long as six months. While a single dose has a rapid effect, can take five days of use. The pain relieving effects last about six hours a single dose, similar to morphine’s. After long term use, in people with normal liver function, effects last 8 to 36 hours.
Side effects are similar to those of other opioids. Commonly these include dizziness, sleepiness, vomiting, and sweating. Serious risks include opioid abuse and a decreased effort to breathe. The number of deaths in the United States involving methadone poisoning declined from 4,418 in 2011 to 3,300 in 2015. Risks are greater with higher doses. Methadone made by chemical synthesis and acts on opioid receptors..
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